Allylic C(sp3)–H alkylation via synergistic organo- and photoredox catalyzed radical addition to imines

Jiaqi Jia, Rajesh Kancherla, Magnus Rueping, Long Huang
Chemical Science, (2020)


Photoredox catalysis, Homoallylamines , Imines


A new catalytic method for the direct alkylation of allylic C(sp3)–H bonds from unactivated alkenes via synergistic organo- and photoredox catalysis is described. The transformation achieves an efficient, redox-neutral synthesis of homoallylamines with broad functional group tolerance, under very mild reaction conditions. Mechanistic investigations indicate that the reaction proceeds through the N-centered radical intermediate which is generated by the allylic radical addition to the imine.


DOI: 10.1039/d0sc00819b


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