Hydrogenation or Dehydrogenation of N‑Containing Heterocycles Catalyzed by a Single Manganese Complex

Viktoriia Zubar, Jannik C. Borghs, Magnus Rueping
Organic Letters, (2020)

Keywords

Organic reactions, Heterocyclic compounds, Catalysts, Indoles, Hydrogenation

Abstract

​A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism.

Code

https://doi.org/10.1021/acs.orglett.0c01273

Sources

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