Hydrogenation or Dehydrogenation of N‑Containing Heterocycles Catalyzed by a Single Manganese Complex
Viktoriia Zubar, Jannik C. Borghs, Magnus Rueping
Organic Letters, (2020)
Organic reactions, Heterocyclic compounds, Catalysts, Indoles, Hydrogenation
A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism.