Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation†

Patricia E. Krach, Abhishek Dewanji, Tingting Yuan, Magnus Rueping
Chemical Communications, (2020)


Nickel catalyst, Benzylic acylation reaction


​Herein, we report a dual catalytic system for the direct benzylic C–H acylation reaction furnishing a variety of unsymmetrical ketones. A benzophenone-derived photosensitizer combined with a nickel catalyst has been established as the catalytic system. Both acid chlorides and anhydrides are able to acylate the benzylic position of toluene and other methylbenzenes. The method offers a valuable alternative to late transition metal catalyzed C–H acylation reactions.



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