Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones

Iuliia Polishchuk, Jan Sklyaruk, Yury Lebedev, and Magnus Rueping
Chemistry A European Journal, (2021)


Reductive amination, primary amines, iridium catalysis, deuteration


​Half‐sandwich iridium complexes bearing bidentate urea‐phosphorus ligands were found to catalyze the direct reductive amination of aromatic and aliphatic ketones under mild conditions at 0.5 mol.% loading with high selectivity towards primary amines. One of the complexes was found to be active in both the Leuckart‐Wallach (NH4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atmosphere, dry solvents, as well as additives and in contrast to previous reports takes place in HFIP instead of methanol. Applying NH4CO2D or D2 resulted in a high degree of deuterium incorporation into the primary amine α‐position.



Website PDF