A. Chatupheeraphat, H.H. Liao, S. Mader, M. Sako, H. Sasai, I. Atodiresei, M. Rueping
Angew. Chem. Int. Ed., 55, pp. 4803-4807, (2016)
An enantioselective addition of thiols and alcohols to aza-ortho-quinone methides, starting from diaryl methanols, was developed. The asymmetric additions occur under mild reaction conditions in the presence of chiral phosphoric acids and furnish the corresponding adducts with excellent yields and enantioselectivities.