Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

Luis Miguel Azofra, Mai Anh Tran, Viktoriia Zubar, Luigi Cavallo, Magnus Rueping, Osama El-Sepelgy
Chemical Communications, (2020)

Keywords

Catalysis, Kinetic resolution

Abstract

​An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman's sulfinamide as a versatile ammonia surrogate. DFT calculations explain the unusual finding of the highly stereoselective transformation enabled by a catalyst that undergoes an unusual dynamic kinetic resolution.

Code

DOI: 10.1039/d0cc02881a

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