Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation
Luis Miguel Azofra, Mai Anh Tran, Viktoriia Zubar, Luigi Cavallo, Magnus Rueping, Osama El-Sepelgy
Chemical Communications, (2020)
Catalysis, Kinetic resolution
An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman's sulfinamide as a versatile ammonia surrogate. DFT calculations explain the unusual finding of the highly stereoselective transformation enabled by a catalyst that undergoes an unusual dynamic kinetic resolution.