Bi-functional modified-phosphate catalyzed the synthesis of α-α' -(EE)-bis(benzylidene)-cycloalkanones: microwave versus conventional-heating

A. Solhy, W. Amer, M. Karkouri, R. Tahir, A. El Bouari, A. Fihri, M. Bousmina, M. Zahouily
Journal of Molecular Catalysis A: Chemical, 336, pp. 815, (2011)

Bi-functional modified-phosphate catalyzed the synthesis of α-α

Keywords

Cross-aldol Condensation,  --(EE)-bis(benzylidene)-cycloalkanones,   Hydroxyapatite,   Modified hydroxyapatite; Heterogeneous catalysis,  Water,  Conventional heating,  Microwave irradiation

Abstract

​The impregnation of hydroxyapatite (HAP) by NaNO3 leads to a modified-hydroxyapatite which has a bi-functional acid-base property. Sodium-modified-hydroxyapatite (Na-HAP) efficiently catalyzed the cross-aldol condensation of arylaldehydes and cycloketones to afford α-α′-(EE)-bis(benzylidene)-cycloalkanones in good yields under microwave irradiation. Moreover, the methodology described in this paper provides a very easy and efficient synthesis carried out in water as the greenest available solvent under conventional heating. A comparison study between these two different modes of heating was investigated. The catalyst was easily recovered and efficiently re-used.

Code

DOI:  10.1016/j.molcata.2010.11.032

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