Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

F. Wang, W. Zhang, J. Zhu, H. Li, K.-W. Huang, J. Hu
Chem. Commun., 47, pp. 2411-2413, (2010)

Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes

Keywords

Difluorocarbene

Abstract

​A chloride ion-catalyzed generation of difluorocarbene from a relatively non-toxic and inexpensive precursor, Me3SiCF2Cl (1), under mild and neutral conditions leads to an efficient preparation of gem-difluorocyclopropenes and difluorocyclopropanes through [2 + 1] cycloaddition reactions with alkynes and alkenes, respectively.

Code

DOI: 10.1039/C0CC04548A

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