Asymmetric H–D exchange reactions of fluorinated aromatic ketones

Y. Zhao, X. Lim, Y. Pan, L. Zong, W. Feng, C.-H. Tan, K.-W. Huang
Chem. Commun., 48, pp. 5479-5481, (2012)

Asymmetric H–D exchange reactions of fluorinated aromatic ketones

Keywords

Asymmetric HD exchange reactions

Abstract

​Chiral bicyclic guanidine catalyzes the asymmetric H–D exchange reactions. Up to 30% ee was achieved. DFT calculations were employed to elucidate and explain the origin of the reaction's stereoselectivity.

Code

DOI: 10.1039/C2CC31443F

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