[Pd(IPr*)(cinnamyl)Cl]: an efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki–Miyaura cross-coupling
A. Chartoire, M. Lesieur, L. Falivene, A.M.Z. Slawin, L. Cavallo, C.S.J. Cazin, S.P. Nolan
Chemistry - A European Journal, 18, 4517-4521, (2012)
SuzukiMiyaura cross-coupling, N-heterocyclic carbene (NHC)
The bigger the better: The new well-defined [Pd(IPr*)(cin)Cl] pre-catalyst is described (see scheme). This complex proves to be highly active in the Suzuki–Miyaura cross-coupling for the synthesis of tetra-ortho-substituted biaryls under mild conditions. IPr* is reported as the largest N-heterocyclic carbene (NHC) to date for [Pd(NHC)(cin)Cl] complexes, explaining the high reactivity observed for this complex in this challenging transformation.
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