Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

Y. Huang, X. Fang, X. Lin, H. Li, W. He, K.-W. Huang, Y. Yuan, Z. Weng
Tetrahedron, 68, 9949-9953, (2012)

Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

Keywords

Copper catalyst,  Electrophilic trifluoromethylation reaction,  Trifluoromethylarenes

Abstract

​An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups.

Code

DOI:  10.1016/j.tet.2012.09.083

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