An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides

Z. Weng, W. He, C. Chen, R. Lee, D. Tan, Z. Lai, D. Kong, Y. Yuan, K.-W. Huang
Angewandte Chemie International Edition, 52, 1548-1552, (2013)

An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides

Keywords

copper, cross-coupling, C-S bonds, trifluoromethylthiolation                

Abstract

​A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields.                

Code

DOI: 10.1002/anie.201208432                

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