Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles
R. Borrmann, N. Knop, M. Rueping
Chem. Eur. J. 2017, 23, 798, (2016)
Asymmetric Synthesis, Active Spirocyclic, Enantioselective Reduction of Indoles
An enantioselective synthesis of spirocyclic indoline scaffolds was
achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles.
Low catalyst loadings and mild reaction conditions provide a broad
range of differently substituted products with excellent yields and
enantioselectivities. The developed methodology allows an efficient
synthesis of this important spirocyclic structural motif, which is
present in numerous biologically active molecules and privileged
structures in medicinal chemistry.
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