A class of effective decarboxylative perfluoroalkylating reagents: [(phen)2Cu](O2CRF)
Y. Huang, M.J. Ajitha, K.-W. Huang, Z. Zhang, Z. Weng
Dalton Trans., 45, pp. 8468-8474, (2016)
Decarboxylative perfluoroalkylating reagents, Aryl and heteroaryl halides
This article describes the invention of a class of effective reagents [(phen)2Cu](O2CRF) (1) for the decarboxylative perfluoroalkylation of aryl and heteroaryl halides. Treatment of copper tert-butyloxide with phenanthroline ligands, with subsequent addition of perfluorocarboxylic acids afforded air-stable copper(I) perfluorocarboxylato complexes 1.
These complexes reacted with a variety of aryl and heteroaryl halides
to form perfluoroalkyl(hetero)arenes in moderate to high yields.
Computational studies suggested that the coordination of the second phen
ligand may reduce the energy barrier for the decarboxylation of
perfluorocarboxylate to facilitate perfluoroalkylation.
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