Cooperative Organocatalysis of Mukaiyama-Type Aldol Reactions by Thioureas and Nitro Compounds

K. Bukhryakov, V. Desyatkin and V. Rodionov
Chem. Commun., (2016)

Cooperative Organocatalysis of Mukaiyama-Type Aldol Reactions by Thioureas and Nitro Compounds

Keywords

Mukaiyama-type aldol reactions

Abstract

​A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed.

Code

DOI: 10.1039/C6CC01984F

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