Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation

H. Yue, L. Guo, H.-H. Liao, Y. Cai, C. Zhu, M. Rueping
Angew. Chem. Int. Ed., 56, 42-82, (2017)

Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation

Keywords

Catalytic Ester, Amide to Amine Interconversion, Decarbonylative Amination

Abstract

​An efficient nickel-catalyzed decarbonylative amination reaction of aryl and heteroaryl esters has been achieved for the first time. The new amination protocol allows the direct interconversion of esters and amides into the corresponding amines and represents a good alternative to classical rearrangements as well as cross coupling reactions.

Code

DOI: 10.1002/anie.201611819

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