Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides

M. Sicignano, R. Schettini, L. Sica, G. Pierri, F. De Riccardis, I. Izzo, B. Maity, Y. Minenkov, L. Cavallo, G. Della Sala
Chemistry a European Journal, (2019)

Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides

Keywords

K+crown

Abstract

In our opinion, the most innovative aspect of this work is the application of the “arylogy concept” to phthalides. The possibility of introducing groups at the apparently poorly reactive unfunctionalized γ‐position of phthalides, under mild conditions and in a stereoselective fashion, opens up new synthetic opportunities to access valuable natural compounds and their analogues.

Code

DOI: 10.1002.201901253

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