Catalytic C1‐Alkylation with Methanol and Isotope Labelled Methanol

J. Sklyaruk, J. Borghs, O. El-Sepelgy, M. Rueping
Angew. Chem. Int. Ed. 2019, 58, 775-779, (2019)

Catalytic C1‐Alkylation with Methanol and Isotope Labelled Methanol

Keywords

C1-alkylation, Trideuteromethylation, Manganese

Abstract

​A new metal catalyzed protocol for the C1‐methylation has been developed. By employing an air and moisture stable catalyst together with isotopically labelled methanol a series of D‐, CD3‐ and 13C‐labelled products were obtained with good yields under mild reaction conditions with water as the only side product.

Code

DOI: 10.1002/anie.201810885

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