Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis

L. Huang, C. Zhu, L. Yi, H. Yue, R. Kancherla, M. Rueping
Angewandte, (2019)

Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis

Keywords

Cross-Coupling, Dienes, Photoredox and Nickel Catalysis

Abstract

Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in CC bond saturation.

Code

DOI: 10.1002/anie.201911109

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