Electrochemical and Scalable Dehydrogenative C(sp3)−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow

P. Nikolaienko, M. Jentsch, A.P. Kale, Y. Cai, M. Rueping
Chemistry a European Journal, (2019)

Electrochemical and Scalable Dehydrogenative C(sp3)−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow

Keywords

1,5-HAT, Amination, Electrosynthesis, Flow electrolysis, Pyrrolidines

Abstract

​A hydrogen atom transfer‐directed electrochemical intramolecular C−H amination has been developed in which the N‐radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.

Code

DOI: 10.1002/chem.201806092

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