Chemo- and Regioselective Magnesium-Catalyzed ortho-Alkenylation of Anilines

A. Chatupheeraphat, M. Rueping, M. Magre
Organic letters, (2019)

Chemo- and Regioselective Magnesium-Catalyzed ortho-Alkenylation of Anilines

Keywords

Detailed characterization of products, H and NMR spectra

Abstract

​A simple and efficient catalytic system for a chemo- and regioselective ortho-alkenylation of anilines is presented. The new magnesium-catalyzed reaction allows the use of a wide range of alkynes and anilines with different electronic and steric properties and provides free as well as protected anilines with excellent yields.

Code

DOI: 10.1021/acs.orglett.9b03526

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