Magnesium‐Catalyzed Hydroboration of Terminal and Internal Alkynes

M. Magre, B Maity, A. Falconnet, L. Cavallo, M. Rueping
Angewandte Chemie - International Edition, (2019)

Magnesium‐Catalyzed Hydroboration of Terminal and Internal Alkynes

Keywords

Alkynes, DFT, Hydroboration, Magnesium, Vynil Borane

Abstract

​A magnesium‐catalyzed hydroboration of alkynes providing good yields and selectivities for a wide range of terminal and symmetrical and unsymmetrical internal alkynes has been developed. The compatibility with many functional groups makes this magnesium catalyzed procedure attractive for late stage functionalization. Experimental mechanistic investigations and DFT calculations reveal insights into the reaction mechanism of the magnesium catalyzed protocol.

Code

DOI: 10.1002/anie.201902188

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