Nickel-Catalyzed Exo-Selective Hydroacylation/Suzuki Cross-Coupling Reaction

S.-C. Lee, L. Guo, M. Rueping
Chemical Communications, (2019)

Nickel-Catalyzed Exo-Selective Hydroacylation/Suzuki Cross-Coupling Reaction

Keywords

Nickel-catalyzed

Abstract

​The first nickel-catalyzed intramolecular hydroacylation/Suzuki cross coupling of o-allylbenzaldehydes with a broad range of phenylboronic acid neopentyl glycol esters has been developed. This strategy shows high regioselectivity and step economy in the construction of two C-C bonds via aldehyde C-H bond activation, affording valuable indanones with high efficiency. Furthermore, experimental results suggest that boronates act as both synthetic building blocks and hydride transfer reagents.

Code

DOI: 10.1039/C9CC07558E

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