N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

O. Santoro, F. Lazreg, Y. Minenkov, L. Cavallo, C. S. J. Cazin
Dalton Trans. 44, 18138, (2016)

N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Keywords

N-methylation, CO2

Abstract

​The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

Code

DOI: 10.1039/C5DT03506F

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