Artificial Metalloenzymes - Integrating Homogeneous and Biocatalysis for Selective Transformation of Alkenes

Artificial metalloenzymes have emerged as a promising approach to combine the attractive properties of homogeneous and biocatalysts. The high degree of control of secondary interactions potentially circumvents the selectivity challenges and facilitates corporative activation strategies for olefin transformations. However, to transform artificial metalloenzymes into valuable catalysts that can be applied in alkene transformations, several challenges need to be addressed. Next to the targeted synthesis of metalloenzymes with carefully designed catalytic active sites using a synergistic organometallic and biotechnological approach, facets with regard to reaction media, solubility or substrate accessibility have to be adjusted. These methodological challenges are similar to those mentioned in project A and will be addressed synergistically in order to develop a new set of catalytic olefin transformations.

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