Ideal chemical transformations have enormous impact on resources, energy, and environment.[1] Recent advancement in chemical synthesis have been witnessed on the use of non-toxic reagents, environmentally benign transition metals, and reagent free synthesis (energy transfer catalysis) towards the sustainable development.[2] In this regard, transition metal catalysis revolutionize the organic synthesis by minimizing the use of strong base, toxic reagents, multi-step synthesis etc. To further advance the sustainable synthesis, use of 3d-metals has been widely explored over the last decade for two sustainable catalytic processes, i.e., C-H bond functionalizations[3] and borrowing hydrogen chemistry.[4] In this lecture, I will discuss the advantages and unique reactivity of high-valent cobalt over the in-situ generated low-valent cobalt for C-H bond functionalizations and its mechanistic pathways.[5] Also, I will discuss briefly about our recent report on the discovery of new mechanism in redox active metals.5
[2] (a) Ludwig, J. R.; Schindler, C. S. Chem. 2017, 2, 313-316. (b) Liu, J.; Lu, L.; Wood, D.; Lin, S. ACS Catal. 2020, 6, 1317-1340.
[3] (a) Gandeepan, P.; Müller, T.; Zell, D.; Cera, G.; Warratz, S.; Ackermann, L. Chem. Rev. 2019, 119, 2192-2452. (b) Mandal, R.; Garai, B.; Sundararaju, B. ACS Catal. 2022, 12, 3452.
[4] Kempe, R.; Irrgang, T. Chem. Rev. 2019, 119, 2524-2549.
[5] (a) Sen, M.; Kalsi, D.; Sundararaju, B. Chem. Eur. J. 2015, 21, 15529-33. (b) Barsu, N.; Sen, M.; Premkumar, J. R.; Sundararaju, B. Chem. Comm. 2016, 52, 13328. (c) Kalsi, D.; Laskar, R. A.; Barsu, N.; Premkumar, J. R.; Sundararaju, B.; Org. Lett. 2016, 18, 4198-4201. (d) Sen, M.; Emayavaramban, B.; Barsu, N.; Premkumar, J. R.; B. Sundararaju, ACS Catal. 2016, 6, 2792-2796. (e) Barsu, N.; Bolli, S. K.; Sundararaju, B. Chem. Sci. 2017, 8, 2431. (f) Kalsi, D.; Dutta, S.; Barsu, N.; Rueping, M.; Sundararaju, B. ACS Catal. 2018, 8, 8115-8120. (g) Chakraborty, P.; Gangwar, M. K.; Manoury, E.; Poli, R.; Sundararaju, B. Chemsuschem, 2019, 12, 3463-3467. (h) Chakraborty, P.; Garg, N.; Manoury, E.; Poli, R.; Sundararaju, B. ACS Catal, 2020, 10, 8023-8031. (i) Chakraborty, P.; Sundararaju, B.; Manoury, E.; Poli, R.; ACS Catal, 2021, 11, 11906.
Indian Institute of Technology Kanpur