Sam Mathew, Ph.D.

Alumni and Former Staff

​Postdoctoral Fellow

Alumni and Former Staff

Research Interest

​My research focuses on insilico discovery of novel biocatalysts especially from extremophiles, cloning and expression of enzymes in microbial hosts, purification and characterization of enzymes, biocatalytic synthesis of industrially relevant chiral compounds.

Selected Publications

  • Production of chiral β-amino acids using ω-transaminase from Burkholderia graminis 
    S. Mathew, H. Bea, S.P. Nadarajan, T. Chung, H. Yun
    Journal of Biotechnology, 196-197:1-8, (2015)
  • Engineering transaminase for stability enhancement and site specific immobilization through multiple non-canonical ... 
    K. Deepankumar, S.P. Nadarajan, S. Mathew, S.G. Lee, T.H. Yoo, E.Y. Hong, H. Yun
    ChemCatChem, 7, 417-421, (2014)
  • Enzymatic synthesis of chiral γ-amino acids using ω-transaminase 
    M. Shon, R. Shanmugavel, G. Shin, S. Mathew, S.H. Lee, H. Yun
    Chemical Communications, 50, 12680-12683, (2014)
  • Enhancing thermostability and organic solvent tolerance of ω-transaminase through global incorporation of fluorotyr... 
    K. Deepankumar, M. Shon, S.P. Nadarajan, G. Shin, S. Mathew, N. Ayyadurai, B.G. Kim, S.H. ...
    Advanced Synthesis Catalysis, 356, 993-998, (2014)
  • One-pot one-step deracemization of amines using ω-transaminases 
    G. Shin, S. Mathew, M. Shon, B.G. Kim, H. Yun
    Advanced Synthesis Catalysis, 356, 993-998, (2013)
  • ω-transaminases for the production of amines and unnatural amino acids 
    S. Mathew, H. Yun
    ACS Catalysis, 2, 993-1001, (2012)


  • Ph.D., Biochemistry, Yeungnam University, Gyeongsan, South Korea, 2016 
  • M.Tech. Bioinformatics, SASTRA University, Tamil Nadu, India, 2007
  • M.Sc. Bioinformatics, Bharathidasan University, Tamil Nadu, India, 2005
  • B.Sc. Computer Applications, Mahatma Gandhi University, Kerala, India, 2002

Professional Profile

  • 2018-present: Postdoctoral fellow, KAUST, Thuwal, Saudi Arabia
  • 2016-2018: Postdoctoral fellow, University of Groningen, Groningen, Netherlands 
  • 2016-2016: Postdoctoral fellow, Konkuk University, Seoul, South Korea
  • 2011-2012: Researcher, Yeungnam University, Gyeongsan, South Korea
  • 2007-2010: Lecturer, Karunya University, Tamil Nadu, India

KAUST Affiliations

  • KAUST Catalysis Center(KCC)
  • Division of Physical Science and Engineering(PSE)

Research Interests Keywords

Enzyme discovery biocatalysis and biotransformation